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Ms. Santhinissi Addala

B.Sc. (Life Sciences)

Juniorette Assistant Professor,

Head of the Branch (HoB),

Stem Cell Biology Branch, 

Department of Intramural Research Core (IRC)

The Center for Advanced-Applied Biological Sciences & Entrepreneurship (TCABS-E), Visakhapatnam (A.P.) India.

Telephone: +91 8660301662; Email: tcabse.india(at)gmail(dot)com.

NIH Biosketch coming soon...

Research Interests: Stem Cell Biology Applications

Stem cells are critical in a lot of medical applications these days because of their high proliferative capacity and self-renewal characteristics. There are many sources for adult stem cells such as the embryo and bone marrow. However the stem cell acquisition from bone marrow is not only invasive but also painful while embryonic stem cell acquisition has ethical issues. In order to circumvent such hurdles the endometrium-derived menstrual stem cells (MnSc) were chosen as a potential source of adult stem cells for organoid development. MnScs can be obtained from volunteers in a non-invasive method and have been previously shown to have differentiation capabilities although not as efficiently as the embryonic stem cells. In this study, the MnScs will be used to develop organoids that have a plethora of medical applications.

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Publications (Listed Chronologically)

  1. Addala, S., Yedidi, R.S. (2020) Impact of COVID-19 on culture and society TCABSE-J, Spl. issue 1:17-21. Epub: Oct25 th , 2020. (View publication)

  2. Vissapragada, M., Addala, S., Sodasani, M., Yedidi, R.S. (2021) Major structural deviations in the receptor binding domain of SARS-CoV-2 spike protein may pose threat to the existing vaccines. TCABSE-J, Vol. 1, Issue 1:12-14. Epub: Apr 13th, 2021. (View publication)

  3. Addala, S., Yedidi, R.S. (2021) Endometrium-derived menstrual stem cells as a potential source of adult stem cells for organoid development. TCABSE-J, Vol. 1, Issue 2:12-14. Epub: Oct 15th , 2021. (View publication)

  4. Addala, S., Yedidi, R.S. (2021) Potential role of vaginal microbiome on the viability of endometrium-derived stem cells for organoid development. TCABSE-J, Vol. 1, Issue 2:31-32. Epub: Oct15 th , 2021. (View publication)

  5. Vissapragada, M., Addala, S., Grandhi, A.V.K.S., Gampa, S., Yedidi, R.S. (2021) Analysis of the wild type SARS-CoV-2 spike protein-mRNA secondary structure stability to predict viral fitness. TCABSE-J, Vol. 1, Issue 2:38-40. Epub: Oct15th , 2021. (View publication)

  6. Gampa, S., Aggunna, M., Grandhi, A.V.K.S., Adduri, V., Ayithamsetti, P., Korabu, M., Addala, S., Vissapragada, M., Palakurty, M., Yedidi, R.S.  (2022) Increase in the predicted mRNA stability of certain SARS CoV-2 mutant spike proteins compared to wild type may pose potential risk to vaccines. TCABSE-J, Vol. 1, Issue 3:4-9. Epub: Apr 2nd, 2022. (View publication)

  7. Addala, S., Vissapragada, M., Aggunna, M., Mukala, N., Lanka, M., Gampa, S., Sodasani, M., Chintalapati, J., Kamidi, A., Veeranna, R.P., Yedidi, R.S. (2022) Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design. Vaccines. 2022; 10(6):841. https://doi.org/10.3390/vaccines10060841