Ms. Manisha Lanka
Department of Intramural Research Core (IRC)
The Center for Advanced-Applied Biological Sciences & Entrepreneurship (TCABS-E), Visakhapatnam (A.P.) India.
Telephone: +91 8660301662; Email: tcabse.india(at)gmail(dot)com.
Research Interests: Micro-RNA Therapeutics delivery: Micro-RNA (miR) molecules have been widely used as therapeutics, especially in Oncology. However, delivery of miRs has been a challenge due to structural instability and side effects of the delivery vehicles. My goal is to identify novel approaches for therapeutic miR delivery. I chose to use Synthetic Biology and protein-based liquid-liquid phase separation condensates as novel delivery vehicles.
Publications (Listed Chronologically)
Lanka, M. and Yedidi, R.S. (2021). Novel strategies for targeted delivery of therapeutic microRNA molecules. TCABSE-J, Vol. 1, Issue 2:18-20. Epub: Oct 15th , 2021. (View publication)
Addala, S., Vissapragada, M., Aggunna, M., Mukala, N., Lanka, M., Gampa, S., Sodasani, M., Chintalapati, J., Kamidi, A., Veeranna, R.P., Yedidi, R.S. (2022) Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design. Vaccines. 2022; 10(6):841. https://doi.org/10.3390/vaccines10060841
Lanka, M., Sodasani, M. and Yedidi, R.S. (2022). Novel biophysical strategy for the delivery of therapeutic microRNA molecules for Cancer and infectious diseases treatment. TCABSE-J, Vol. 1, Issue 4:9-17. Epub: Oct 5th , 2022. (View publication)