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Mr. Manikanta Sodasani

B.Pharm. 

TCABS-E Scientist,

Program Manager,

Biophysics, 

Department of Intramural Research Core (IRC)

The Center for Advanced-Applied Biological Sciences & Entrepreneurship (TCABS-E), Visakhapatnam (A.P.) India.

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Telephone: +91 8660301662; Email: tcabse.india(at)gmail(dot)com.

Research Interests: Protein liquid-liquid phase separations: Delivery of drugs and pharmaceuticals is always challenging while composing the oral and IV formulations. No matter how specific a given drug can be, the precise delivery to the target is critical to decrease the systemic toxicity. My goal is to take advantage of the protein liquid-liquid phase separations (LLPS) to deliver therapeutic RNA molecules including drugs and pharmaceuticals. We have currently shortlisted a few intrinsically disordered proteins that exhibit LLPS nature and are evaluating them with different formulations for the delivery of RNA therapeutics.

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Patents

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  • Hemsai, P., Sodasani, M. and Yedidi, R.S. (2023). An atherosclerotic plaque detection kit and method of early detection of arterial plaques in patients. Indian Patent No. IN202341017482A.

  • Sodasani, M., Hemsai, P. and Yedidi, R.S. (2023). A method for estimating enzyme activity by combining native polyacrylamide gel electrophoresis with zymography. Indian Patent No. IN202341073807A.

  • Sirihanuma, V., Sodasani, M. and Yedidi, R.S. (2024). A method for extracting and invetigating antibacterial properties of sulforaphane from broccoli. Indian Patent No. IN202441056118A.

  • Achyuthavallidevi, Y., Sivakumar, N., Sodasani, M., Girijasastry, V. and Yedidi, R.S. (2024). A method for extracting lecanoric acid from Parmotrema praesorediousm for antimicrobial applications. Indian Patent No. IN202441076617A.

  • Achyuthavallidevi, Y., Sivakumar, N., Sodasani, M., Girijasastry, V. and Yedidi, R.S. (2025). A method for isolating atraric acid from Parmotrema reticulatum for antimicrobial agents. Indian Patent No. IN202541013616A.

  • Bharathalakshmi, B., ..., Sodasani, M. and Yedidi, R.S. (2025). A Multi-Biomarker Diagnostic Kit for Detecting Migraine in Patients and Method Thereof. Indian Patent No. IN202541053079A.

Publications (Listed Chronologically)

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  1. Vissapragada, M., Addala, S., Sodasani, M., Yedidi, R.S. (2021) Major structural deviations in the receptor binding domain of SARS-CoV-2 spike protein may pose threat to the existing vaccines. TCABSE-J, Vol. 1, Issue 1:12-14. Epub: Apr 13th, 2021. (View publication)

  2. Sodasani, M. and Yedidi, R.S. (2021) Leveraging the protein liquid-liquid phase separation droplets as potential drug delivery vehicles. TCABSE-J, Vol. 1, Issue 2:28-30. Epub: Oct 15th , 2021. (View publication)

  3. Addala, S., Vissapragada, M., Aggunna, M., Mukala, N., Lanka, M., Gampa, S., Sodasani, M., Chintalapati, J., Kamidi, A., Veeranna, R.P., Yedidi, R.S. (2022) Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design. Vaccines. 2022; 10(6):841. https://doi.org/10.3390/vaccines10060841

  4. Lanka, M., Sodasani, M. and Yedidi, R.S. (2022). Novel biophysical strategy for the delivery of therapeutic microRNA molecules for Cancer and infectious diseases treatment. TCABSE-J, Vol. 1, Issue 4:9-17. Epub: Oct 5th , 2022. (View publication)

  5. Vissapragada, M., Addala, S., Aggunna, M., Mukala, N., Chintalapati, J., Kamidi, A., Korabu, M. S., Lanka, M., Palla, H., Sodasani, M., Grandhi, A. V. K. S., Unnisa, A., Adhikari, A., Kumpatla, A. D., Yerabolu, B., Paidi, C., Pemmadi, G., Penta, H., Mallavalli, H., Gadigoyala, K., Voleti, M., Ravilisetty, M., Akula, N., Gundubogula, P., Puripanda, P., Lankapalli, P., Sandipamu, P., Nagraj, R., Tamarala, R., Geddam, R., Kolluru, R., Oggu, R., Garbhapu, R., Meka, S., Geddam, S., Viyyapu, S., Sammangi, S., Javvaji, S., Chattopadhyay, S., Inemella, S., Grandhi, V., Chigilipalli, Y., Puppala, Y. C., Sharma, M. H., Gubbala, S., Thakur, K., Aanaparthi, S., Pothula, B. and Yedidi, R.S. (2022). In silico analysis of molnupiravir usage vs. efficacy of COVID-19 vaccines. TCABSE-J, Vol. 1, Issue 5:1-14. Mar 22nd, 2023. Epub: Oct 20th, 2022. (View publication)

  6. Tamarala, R., Chintalapati, J., Sodasani, M., Grandhi, A.V.K.S. and Yedidi, R.S. (2023). Proton NMR spectral data of adulterated tea samples suggest possible causes for various human gut-related diseases. TCABSE-J, Vol. 1, Issue 5:33-35. Mar 22nd, 2023. Epub: Mar 20th, 2023. (View publication)

  7. Karri, L., Sodasani, M., Addala, S., Grandhi, A.V.K.S., Chintalapati, J. and Yedidi, R.S. (2023). Proton-NMR-based comparative analysis of aqueous vs. organic extractions from Ficus religiosa with potential applications in the treatment of polycystic ovarian syndrome. TCABSE-J, Vol. 1, Issue 6:4-8. (View publication)

  8. Sodasani, M., Bukka, S., Mukala, N., Panchagnula, B., Pola, S. and Yedidi, R.S. (2023). In vitro comparative analysis of leaky protein expression in the BL21 strain vs. DH5α strain of E. coli. TCABSE-J, Vol. 1, Issue 6:15-17. (View publication)

  9. Vissapragada, M., Gollu, S., Addala, S., Sodasani, M., Aggunna, M., Mukala, N., Pola, S., Panchagnula, B. and Yedidi, R.S. (2023). PCR amplification of wild type receptor binding domain coding gene of SARS CoV-2 spike protein for cloning into a bacterial expression vector. TCABSE-J, Vol. 1, Issue 6:18-23. (View publication)

  10. Sundaram, B., Akula, L., Akella, M.V.S., Mir, H.T., Shaik Azeez, Lebesa, M.N., Allu, J., Agathambadi, K., Sodasani, M., Aggunna, M., Addala, S., Vissapragada, M. and Yedidi, R.S. (2024). Exploring the street food bacterial diversity in the city of destiny using the bacterial 16S rRNA genotyping. TCABSE-J, Vol. 1, Issue 7:21-25. (View publication)

  11. Simhadri, P.V., Addala, S., Sodasani, M. and Yedidi, R.S. (2024). Biodegradable organic perfumes are eco-friendly and healthy compared to the synthetic perfumes. TCABSE-J, Vol. 1, Issue 7:32-34. (View publication)

  12. Bellana, P., Eddumala, N., Pinipe, J., Marada, K., Mahapatro, R., Addala, S., Sodasani, M. and Yedidi, R.S. (2024). In vitro horizontal transfer of ampicillin-resistance gene between bacterial species with implications in antibiotic-resistance problem in human microbiome. TCABSE-J, Vol. 1, Issue 8:1-5. (View publication)

  13. Sampadarao, K., Mallapureddi, M., Valluri, P., Kolluri, A., Kolli, S., Sodasani, M., Vissapragada, M. and Yedidi, R.S. (2024). Mass spectroscopy-based metabolic profiling of marine algal extract that exhibited in vitro antibacterial activity against laboratory E. coli cells. TCABSE-J, Vol. 1, Issue 8:6-8. (View publication)

  14. Kizito, M.M., Dandusena, U., Sodasani, M., Aggunna, M. and Yedidi, R.S. (2024). Antimicrobial efficacy of toothpastes containing herbal vs. synthetic ingredients against antibiotic-sensitive/-resistant Gram -ve oral bacteria that cause dental caries. TCABSE-J, Vol. 1, Issue 8:9-13. (View publication)

  15. Laskar, S.A., Sodasani, M. and Yedidi, R.S. (2024). In silico identification and QSAR analysis of small molecule inhibitors for glucose transporter 3, a potential drug target for pan cancer treatments TCABSE-J, Vol. 1, Issue 8:19-24. (View publication)

  16. Vissapragada, M., Addala, S., Aggunna, M., Sodasani, M., Grandhi, A.V.K.S. and Yedidi, R.S. (2024). Leveraging the potential of bacterial lateral gene transfer in boosting the efficacy of an edible probiotic prototype yogurt vaccine for COVID-19. Biochemical and Biophysical Research Communications, Vol. 734,150622. (View publication)

  17. Aggunna, M., Akula, N., Yanamadala, A.S., Penta, H., Geddam, S., Kota, S., Badugu, S., Muttyala, K., Sodasani, M., Kumar, R., Akondi, R.V., Panchagnula, B., Pola, S., Sala, Y., Ravuri, S., Tsalla, R. and Yedidi, R.S. (2025). Antibiotic-resistance exhibited by clinical isolates of Helicobacter pylori: reality check vs. an artifact of the in vitro assay while deciding the treatment regimen. TCABSE-J, Vol. 1, Issue 9:5-9. (View publication)

  18. Moyyi, D., Pratha, S.V.N.S.S., Kothurthi, Ch., Vangara, R.M., Sreeadibhatla, K., Sundaram, B., Sodasani, M., Alugolu, V. and Yedidi, R.S. (2025). Split-receptor docking, a new strategy to reduce computational demand and cover all potential binding pockets on large receptors: targeting the human thyroglobulin with implications in hyperthyroidism. TCABSE-J, Vol. 1, Issue 9:13-15. (View publication)

  19. Pemmadi, G., Sammangi, S., Mukala, N., Palla, H.Y., Sodasani, M., Chintalapati, J., Grandhi, A.V.K.S., Panchagnula, B., Pola, S. and Yedidi, R.S. (2025). In vitro demonstration of non-specific protein-drug interactions using the equilibrium dialysis binding assay and proton NMR spectroscopy. TCABSE-J, Vol. 1, Issue 9:16-20. (View publication) 

  20. Boddepalli, P., Kolluru, Ch., Chowdari, M., Sodasani, M., Vissapragada, M., Panchagnula, B., Pola, S., Ponamgi, D.S.P. and Yedidi, R.S. (2025). Qualitative and quantitative analysis of SARS CoV-2 spike protein receptor binding domain expression in Lactobacillus with potential applications in edible vaccines. TCABSE-J, Vol. 1, Issue 10:1-3. (View publication)

  21. Sodasani, M., Grandhi, A.V.K.S., Mukala, N., Chintalapati, J., Vissapragada, M., Aggunna, M. and Yedidi, R.S. (2025) Receptor binding domain of SARS CoV2 spike protein exhibits in vitro liquid-liquid phase separation due to structural disorderedness that may challenge the vaccine-generated antibody binding. Biochim Biophys Acta Gen Subj., Vol. 1870 (1), 130889. (View publication)

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tcabse.india@gmail.com, +91 8660301662

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