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Ms. Madhuri Vissapragada

M.Sc. (Human Genetics)

Juniorette Assistant Professor,

Head of the Branch (HoB),

Synthetic Biology Branch, 

Department of Intramural Research Core (IRC)

The Center for Advanced-Applied Biological Sciences & Entrepreneurship (TCABS-E), Visakhapatnam (A.P.) India.

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Telephone: +91 8660301662; Email: tcabse.india(at)gmail(dot)com.

NIH Biosketch coming soon...

Research Interests: Synthetic Biology Applications

Polyethylene Terephthalate (PET) is one of the majorly produced plastics which has a wide range of applications from household to industrial fields. The accumulation of PET plastics and related pollution in the environment have been global concerns for many years. The PET plastic production has increased to more than 500 billion tonnes in the year 2021. The discovery of PET degrading enzymes such as the PETase, etc. from a bacterium called Ideonella sakaiensis has opened new opportunities for many potential approaches to develop an efficient plastic biodegradation system. Out of many platforms available for this, we believe that synthetic biology approach can be the most effective way for the development of a novel system which is safe and efficient for the biodegradation of PET plastics.

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Patents

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  • Vissapragada, M., Aggunna, M. and Yedidi, R.S. (2023). A probiotic vaccine for preventing coronavirus infection and preparation method. Patent No. 202341008573.

  • Vissapragada, M., Addala, S. and Yedidi, R.S. (2023). Probiotic vaccines for oral delivery using lateral gene transfer and method thereof. Patent No. 202341074497.

  • Vissapragada, M., Akella, V.S.M. and Yedidi, R.S. (2023). A diagnostic kit for the detection of latent HIV-1 infections using patient blood samples. Patent No. 202341074827.

Publications (Listed Chronologically)

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  1. Koppala, R.S., Vissapragada, M., Yedidi, R.S. (2020) Triplet codons to amino acids: Applications of machine learning approaches to protein translation made simple for college students. TCABSE-J, Spl. issue 1:3-6. Epub: Oct 25th, 2020. (View publication)​

  2. Vissapragada, M., Addala, S., Sodasani, M., Yedidi, R.S. (2021) Major structural deviations in the receptor binding domain of SARS-CoV-2 spike protein may pose threat to the existing vaccines. TCABSE-J, Vol. 1, Issue 1:12-14. Epub: Apr 13th, 2021. (View publication)​

  3. Vissapragada, M., Yedidi, R.S. (2021) Design and development of synthetic bacteria with built in genetic circuits for plastics biodegradation. TCABSE-J, Vol. 1, Issue 2:9-11. Epub: Oct 15th, 2021. (View publication

  4. Vissapragada, M., Addala, S., Grandhi, A.V.K.S., Gampa, S., Yedidi, R.S. (2021) Analysis of the wild type SARS-CoV-2 spike protein-mRNA secondary structure stability to predict viral fitness. TCABSE-J, Vol. 1, Issue 2:38-40. Epub: Oct 15th, 2021. (View publication)​

  5. Gampa, S., Aggunna, M., Grandhi, A.V.K.S., Adduri, V., Ayithamsetti, P., Korabu, M., Addala, S., Vissapragada, M., Palakurty, M., Yedidi, R.S.  (2022) Increase in the predicted mRNA stability of certain SARS CoV-2 mutant spike proteins compared to wild type may pose potential risk to vaccines. TCABSE-J, Vol. 1, Issue 3:4-9. Epub: Apr 2nd, 2022. (View publication)​

  6. Addala, S., Vissapragada, M., Aggunna, M., Mukala, N., Lanka, M., Gampa, S., Sodasani, M., Chintalapati, J., Kamidi, A., Veeranna, R.P., Yedidi, R.S. (2022) Success of Current COVID-19 Vaccine Strategies vs. the Epitope Topology of SARS-CoV-2 Spike Protein-Receptor Binding Domain (RBD): A Computational Study of RBD Topology to Guide Future Vaccine Design. Vaccines. 2022; 10(6):841. https://doi.org/10.3390/vaccines10060841

  7. Vissapragada, M., Addala, S., Aggunna, M., Mukala, N., Chintalapati, J., Kamidi, A., Korabu, M. S., Lanka, M., Palla, H., Sodasani, M., Grandhi, A. V. K. S., Unnisa, A., Adhikari, A., Kumpatla, A. D., Yerabolu, B., Paidi, C., Pemmadi, G., Penta, H., Mallavalli, H., Gadigoyala, K., Voleti, M., Ravilisetty, M., Akula, N., Gundubogula, P., Puripanda, P., Lankapalli, P., Sandipamu, P., Nagraj, R., Tamarala, R., Geddam, R., Kolluru, R., Oggu, R., Garbhapu, R., Meka, S., Geddam, S., Viyyapu, S., Sammangi, S., Javvaji, S., Chattopadhyay, S., Inemella, S., Grandhi, V., Chigilipalli, Y., Puppala, Y. C., Sharma, M. H., Gubbala, S., Thakur, K., Aanaparthi, S., Pothula, B. and Yedidi, R.S. (2022). In silico analysis of molnupiravir usage vs. efficacy of COVID-19 vaccines. TCABSE-J, Vol. 1, Issue 5:1-14. Mar 22nd, 2023. Epub: Oct 20th, 2022. (View publication)

  8. Vissapragada, M., Gollu, S., Addala, S., Sodasani, M., Aggunna, M., Mukala, N., Pola, S., Panchagnula, B. and Yedidi, R.S. (2023). PCR amplification of wild type receptor binding domain coding gene of SARS CoV-2 spike protein for cloning into a bacterial expression vector. TCABSE-J, Vol. 1, Issue 6:18-23. Epub: Aug 20th, 2023. (View publication)

  9. Bellana, P., Eddumala, N., Pinipe, J., Marada, K., Mahapatro, R., Addala, S., Sodasani, M., Vissapragada, M. and Yedidi, R.S. (2024). In vitro horizontal transfer of ampicillin-resistance gene between bacterial species with implications in antibiotic-resistance problem in human microbiome. TCABSE-J, Vol. 1, Issue 8:1-5. Epub: Jul 20th, 2024. (View publication)

  10. Sampadarao, K., Mallapureddi, M., Valluri, P., Kolluri, A., Kolli, S., Sodasani, M., Vissapragada, M. and Yedidi,
    R.S. (2024). Mass spectroscopy-based metabolic profiling of marine algal extract that exhibited in vitro antibacterial activity against laboratory E. coli cells. TCABSE-J, Vol. 1, Issue 8:6-10. Epub: July 24th, 2024. (    View publication)

  11. Teketi, K., Vissapragada, M. and Yedidi, R.S. (2024). In vitro analysis of natural-edible antioxidant
    remedies in reducing the oxidative stress mediated blood coagulation and preventing thrombosis in sickle cell
    disease. TCABSE-J, Vol. 1, Issue 8:14-16. Epub: July 30th, 2024. (View publication)

  12. Vissapragada, M., Addala, S., Aggunna, M., Sodasani, M., Grandhi, A.V.K.S. and Yedidi, R.S. (2024). Leveraging the potential of bacterial lateral gene transfer in boosting the efficacy of an edible probiotic prototype yogurt vaccine for COVID-19. Biochemical and Biophysical Research Communications, Vol. 734,150622. (View publication)

  13. Vissapragada, M., Aggunna, M., Tallapalli, M., Mandugula, H., Devandla, A., Yekula, A., Malapati, A., Bonala, S., Addala, S., Gudapati, S. and Yedidi, R.S. (2024) In silico prediction of COVID-19 vaccine efficacy based on the strain-specific structural deviations in the SARS CoV-2 spike protein receptor binding domain. Medical Research Archives, Vol. 12, No. 9. (View publication)

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