Picture1.png

THE CENTER FOR ADVANCED-APPLIED BIOLOGICAL SCIENCES

& ENTREPRENEURSHIP

Training the future Scientific Entrepreneurs

  • Home

    • About
    • Administration
    • Departments
    • Founder
  • Academics

    • Faculty
    • Research-Core
    • Students
    • Journal club
    • Certificate Courses
    • Internship programs
    • Courses2021
    • JunionScientificInvestigator
    • ScientificEntrepreneurship
    • Drug Discovery
    • Scientist
    • DNAfingerprinting
  • TCABSE-J

    • About TCABSE-J
    • Aims & Scope
    • Authors
    • Editorial_Board
    • Rxive
    • Articles
    • Special Issue
    • Vol1Iss1
    • Vol1Iss2
    • Vol1Iss3
    • Vol1Iss4
  • Events

    • ITvsBT-Seminar
    • ABFR-2019
    • Gallery
    • TOCC
    • ABFR-2020
    • VLSESymposium-2021
  • Contact

  • More

    Use tab to navigate through the menu items.
    Picture11.png

    C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir. (Research article)

    ​

    Journal of Virology

    ​

    Feb 2016, 90 (5) 2180-2194; DOI: 10.1128/JVI.01829-15

    ​

    X-ray structures: PDB IDs: 5COK, 5CON, 5COO and 5COP

    Details
    Picture16.png

    Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex. (Research article)

    ​

    Biochemical and Biophysical Research Communications

    ​

    February 2013, 431(2): 232-238

    ​

    Related X-ray crystal structure: PDB ID: 4EYR

    Details
    Picture12.png

    A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF. (Research article)

    ​

    Journal of Molecular Graphics and Modelling

    ​

    September 2014, 53: 105-111.

    DOI: 10.1016/j.jmgm.2014.06.010

    Related X-ray crystal structure: PDB ID: 4NKK

    Details
    Picture13.png

    A Conserved Hydrogen-Bonding Network of P2 bis-Tetrahydrofuran-Containing HIV-1 Protease Inhibitors (PIs) with a Protease Active-Site Amino Acid Backbone Aids in Their Activity against PI-Resistant HIV. (Research article)

    ​

    Antimicrobial Agents and Chemotherapy

    ​

    Jun 2014, 58 (7) 3679-3688; DOI: 10.1128/AAC.00107-14

    ​

    X-ray structures: PDB IDs: 4NJS, 4NJT, 4NJU and 4NJV

    Details
    Picture14A.png

    P1 and P1′ para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: Structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease. (Research article)

    ​

    Journal of Molecular Graphics and Modelling

    February 2014, 47: 18-24

    DOI: 10.1016/j.jmgm.2013.10.010

    Details
    Picture15.png

    Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes. (Research article)

    ​

    Biochemical and Biophysical Research Communications

     

    January 2013, 430(3): 1022-1027

     

    DOI: 10.1016/j.bbrc.2012.12.045

    Details
    Picture17.png

    Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: Mechanism of drug recognition and resistance. (Research article)

    ​

    Biochemical and Biophysical Research Communications

    ​

    July 2013, 437(2): 199-204

    ​

    Related X-ray crystal structure: PDB ID: 4L1A

    Details
    Picture18a.png

    Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease. (Research article)

    ​

    Biochemical and Biophysical Research Communications

    September 2013, 438(4): 703-708

    DOI: 10.1016/j.bbrc.2013.07.117

    Details
    Picture19.png

    P2′ Benzene Carboxylic Acid Moiety Is Associated with Decrease in Cellular Uptake: Evaluation of Novel Nonpeptidic HIV-1 Protease Inhibitors Containing P2 bis-Tetrahydrofuran Moiety. (Research article)

    ​

    Antimicrobial Agents and Chemotherapy

    ​

    Sep 2013, 57 (10) 4920-4927; DOI: 10.1128/AAC.00868-13

    ​

    X-ray structures: PDB IDs: 4HLA, 4I8W and 4I8Z

    Details
    Picture20.png

    Crystal structure of the extracellular domain of human myelin protein zero. (Structure Note)

    ​

    Proteins (Structure, Function and Bioinformatics)

    ​

    January 2012, 80(1): 307-313; DOI: 10.1002/prot.23164

    ​

    Related X-ray crystal structure: PDB ID: 3OAI

    Details
    Picture21.png

    Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds. (Research article)

    ​

    Biochemical and Biophysical Research Communications

    ​

    May 2012, 421(3): 413-417

    DOI: 10.1016/j.bbrc.2012.03.096

    X-ray crystal structures: PDB IDs: 3R0W and 3R0Y

    Details
    Picture22.png

    Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants. (Research article)

    ​

    Acta Crystallographica Section D Structural Biology

    ​

    June 2011, 67(6): 524-532; DOI: 10.1107/S0907444911011541

    ​

    X-ray structures: PDB IDs: 3PJ6, 3OQ7, 3OQA and 3OQD

    Details
    Picture23.png

    Novel HIV-1 Protease Inhibitors (PIs) Containing a Bicyclic P2 Functional Moiety, Tetrahydropyrano-Tetrahydrofuran, That Are Potent against Multi-PI-Resistant HIV-1 Variants. (Research article)

    ​

    Antimicrobial Agents and Chemotherapy

    Mar 2011, 55 (4) 1717-1727 

    DOI: 10.1128/AAC.01540-10

    Details

    tcabse.india@gmail.com, +91 8660301662

    ©2019 by The Center for Advanced-Applied Biological Sciences & Entrepreneurship. Proudly created with Wix.com