Training the future Scientific Entrepreneurs
Novel Central Nervous System (CNS)-Targeting Protease Inhibitors for Drug-Resistant HIV Infection and HIV-Associated CNS Complications. (Research article)
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Antimicrobial Agents and Chemotherapy.
June 2019, 63 (7) e00466-19; DOI: 10.1128/AAC.00466-19
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AAA-ATPases in Protein Degradation. (Review)
Frontiers in Molecular Biosciences.
June 2017, 4:42.
DOI: 10.3389/fmolb.2017.00042
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Ubiquitin orchestrates proteasome dynamics between proliferation and quiescence in yeast. (Research article)
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Molecular Biology of the Cell.
August 2017, 28(19): 2479-2491.
DOI: 10.1128/AAC.00466-19
GRL-09510, a Unique P2-Crown-Tetrahydrofuranylurethane -Containing HIV-1 Protease Inhibitor, Maintains Its Favorable Antiviral Activity against Highly-Drug-Resistant HIV-1 Variants in vitro. (Research article)
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Nature Scientific Reports.
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September 2017, 7, 12235; doi:10.1038/s41598-017-12052-9.
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Related X-ray crystal structure: PDB ID: 5V4Y
A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency. (Research article)
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eLIFE.
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October 2017, 6, pii: e28020; doi: 10.7554/eLife.28020
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A Modified P1 Moiety Enhances In Vitro Antiviral Activity against Various Multidrug-Resistant HIV-1 Variants and In Vitro Central Nervous System Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413. (Research article)
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Antimicrobial Agents and Chemotherapy.
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November 2016, 60 (12): 7046-7059; DOI: 10.1128/AAC.01428-16
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Related X-ray crystal structure: PDB ID: 5KAO
Proteasome dynamics between proliferation and quiescence stages of Saccharomyces cerevisiae. (Review)
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Critical Reviews in Biochemistry and Molecular Biology.
September 2016, 51:6, 497-512.
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DOI: 10.1080/10409238.2016.1230087
Comparative in silico inter-spin distance analysis of IDSL spin labels modeled on lysozyme mutants against experimentally determined DEER distance measurements. (Conference paper, High Performance Computing Symposium, Kingston, ON, Canada)
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Springer LNCS, in press.